Binding characterization for drug development
Our services and our proprietary software allow us to support decision making in hit validation and lead optimization of drug candidates by Isothermal Titration Calorimetry
ITC is the Gold-standard for the thermodynamic characterization of molecular interactions. BUT there is much more information contained in the ITC experiment that ONLY can be extracted by AFFINImeter.
Our services helped our clients to solve problems like:
RANKING DRUG CANDIDATES: simultaneos analysis of binding kinetics and thermodynamics. Learn more
ELUCIDATION OF COMPLEX BINDING INTERACTION: performing global fitting analysis with tailored binding models. Learn more
BIOSIMILARITY: Comparing drug performance with comertial drugs trough biophysical technique can be enought for regulatory agencies to allow entrance in teh market, saving time and cost. Learn more
Software
AFFINIMETER for
Isothermal Titration Calorimetry
- Provides same information than SPR = kinetics.
- Facilitates NOT ONLY analysis of simple interactions (1:1 models) but also complex interactions creating new tailored binding models in a friendly interface.
- Obtain the same KINETIC PARAMETERS OF INTERACTION (kon and koff)as SPR but in a label-free and in-solution measurement
- Create your own binding models to analyze COMPLEX MECHANISH OF INTERACTIONS as multisite Binding, cooperativity, dimerization induced by binding, competition assays, etc.