Our services and our proprietary software allow us to support decision making in hit validation and lead optimization of drug candidates by Isothermal Titration Calorimetry
Features
ITC is the Gold-standard for the thermodynamic characterization of molecular interactions. BUT there is much more information contained in the ITC experiment that ONLY can be extracted by AFFINImeter.
Data Analysis
Exclusive tools for thermodynamic, kinetic and structural characterization of drug-target interactions
Global Fitting
Use global fitting to assess data quality and reproducibility, and for the robust analysis of complex interactions
Software Development
We design ad-hoc analysis software to improve your workflow
Results
- More accurate ranking of drug candidates by simultaneously analyzing kinetics and thermodynamic by ITC.
- Faster, cheaper and more reliable elucidation of binding mechanism of interaction.
- Confirming drug performance at the molecular level in biosimilarity projects.
Data analysis
Developing our own analytical tools for accurate and reliable analysis of biophysical data. We are specialized in:
- Mechanism of interaction elucidation.
- Characterization of complex binding.
- Kinetic and thermodynamic coherence in multi-technique studies.
Our analysis can cover a large range of different complex interactions:
- Multisite binding.
- Cooperativity interactions.
- Conformational changes.
- Competition experiments.
BINDING CHARACTERIZATION
Our scientific team has broad experience in designing a new protocol for binding characterization using biopysical techniques as:
- Isothermal Titration Calorimetry (ITC).
- Nuclear Magnetic Resonance (NMR).
- Surface Plasmon Resonance (SPR).
- MicroScale Thermophoresis (MST).
As well as computational simulations for:
- Docking.
- Molecular Dynamics (MD).
SOFTWARE DEVELOPMENT
We develop ad hoc software for automatization of acquisition, analysis and store in a database of experimental data. We can optimize your Drug Discovery projects by saving time and money.
Contact us if you are interested in software for:
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- Micellization.
- Screening using Differential Scanning Fluorescence.
- Ranking drug candidate through one-single ITC injection.